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Chomix -Agaroseresins Azide Resin, Acid Cleavable Linker Group
Product Introduction
This product is an azide-modified agarose resin with an acid-cleavable linker group. The biorthogonal functional group, azide, is covalently attached to the resin.The acid-cleavable linker group in this product has an optimized structure with high hydrophilicity to prevent aggregation in solution.It efficiently separates and enriches molecules modified with alkyne groups, including small molecules, proteins, nucleic acids, antibodies, and carbohydrates. Target molecules can be released from the resin under mild acidic conditions.
Data Presentation
Figure 1: Combined with azide coated magnetic beads with cleavable group, super TOP-ABPP experimental time can be reduced to 9 hours
Figure 2: When combined with azide coated magnetic beads with cleavable group, more than 10,000 cysteine peptides can be identified under the same conditions
In 2023, the research group of Professor Wang Chu, the company's chief scientist, from Peking University, published an efficient and concise version of the chemical proteomics experimental protocol in the Journal of Proteome Research (JProteome Res. 2023, 3360-3367). The use of cleavable azide magnetic beads can significantly shorten the analysis time of cysteine peptide groups labeled with chemical probes (Figure 1), while greatly improving the identification rate of modified peptides (Figure 2). Compared with traditional streptavidin magnetic beads, azide magnetic beads have demonstrated superior performance in terms of cost, time, efficiency, etc., and have become a powerful tool in protein research, especially in chemical proteomics-related experimental research.
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