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Photoaffinity probes
Photoaffinity Probes Specialized biochemical tools used in molecular biology and drug discovery to study the interactions between a target molecule (such as a protein) and a small molecule or ligand (mainly non-covalent).Widely used in active small molecule target discovery, off-target protein identification and distribution imaging. Many active small molecule compounds, such as metabolites, natural products, and drug molecules, interact dynamically and reversibly with target proteins in... -
Bioorthogonal Chemical Probes
Bioorthogonal chemical probes Specialized tools used in chemical biology to study and manipulate biological processes within living systems without interfering with the native biochemical processes. Usually designed to perform specific chemical reactions that are both highly selective and inert to the plethora of chemical activities occurring in cells. The reactivity of amino acid residues in proteins plays a crucial role in protein function regulation and drug development. Taking cystei... -
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Bioorthogonal Coupling Reaction Kit
It includes KRASG12D protein, small molecule fluorescent probe, and buffer. The probe uses fluorescence polarization technology to simply and quickly test the affinity of compounds to KRASG12D protein in a high-throughput format.
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ChomixR -Agaroseresins Azide Resin, Acid Cleavable Linker Group
ChomiXR-Magbeads Azide Coated Magnetic Beads are designed by covalently attaching an azide bioorthogonal group to the surface of the magnetic beads. Through non-cleavable ligation group (Figure A) and cleavable ligation group (Figure B)respectively, these beads can be applied to the enrichment of alkyne-modified macromolecules, including proteins, nucleic acids, antibodies and sugars. Over streptavidin (SA) coated magnetic beads, ChomiXR-Magbeads Azide Coated Magnetic Beads have the following advantages:
1. Through the efficient “click chemistry” reaction, the alkyne-modified macromolecules can be directly covalently bound to the magnetic beads, unlike the non-covalent and reversible interaction between streptavidin and biotin. Therefore, the product has higher recovery rate and better repeatability.
2. As there is no protein on the surface of the magnetic beads, the background peptide contamination due to enzymatic digestion will not be introduced. Furthermore, these beads reduce the non-specific adsorption to make samples cleaner, helping to improve the identification efficiency of low-abundance proteins.
3. Chemical molecular modified magnetic beads are stable, making them easier to transport and store.
4. Cleavable azide magnetic beads enable the mild release (using formic acid) of the peptides modified by the chemical probe, which is beneficial for the subsequent mass spectrometry identification.
5. The product is cost-effective, and improves experimental efficiency since it avoids streptavidin-biotin enrichment time.
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ChomiX-Magbeads Streptavidin (SA) Coated Magnetic Beads
ChomiXR-Magbeads Streptavidin (SA) Coated Magnetic Beads, based on the strong binding ability between streptavidin and biotin (kd = 10-14~ -15 mol/L), can highly specific bind with biotinylated proteins or antibodies. They are one of the important tools in the field of life science, widely used in protein separation and enrichment, immunodiagnosis and cell sorting. The beads have a concentration of 10 mg/ml and particle size of 1.0 μ m, with high streptavidin binding capacity(about 50 μ g / 1mg ) and extremely high hydrophilicity. They also exhibit superparamagnetic properties, rapid magnetic response, excellent redispersion stability and magnetic stability, effectively ensuring a high protein binding rate, minimal non-specific adsorption, reaction uniformity, and detection consistency.
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Reagent Kits
Reagent Kits Chemical probes Amino acid residue specific labeling probes Read More Bioorthogonal reaction reagents Read More Post-translational modification of specifically labeled probes Read More Unnatural chemical reporting probes Read More Bifunctional crosslinker Read More Small molecule fluorescent probes Read More
