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Identification of the binding site for non-covalent small molecule drugs in living cells
Identification of the binding site for non-covalent small molecule drugs in living cells At the cellular level, directly studying the mode of action between drugs and target proteins can help avoid changes in protein structure during purification and false-positive results that may arise from artificial buffer systems and high drug-protein concentrations. Technical Platform ChomiX provides chemical proteomics services utilizing biologically active photoreactive chemical probes (with... -
New Therapeutic Prospects for Traditional Medicine: ABPP Technology Unveils Berberine’s Novel Anti-Inflammatory Target EIF2AK2
New Therapeutic Prospects for Traditional Medicine: ABPP Technology Unveils Berberine’s Novel Anti-Inflammatory Target EIF2AK2 Traditional medicine is being revitalized with new pharmacological applications as advanced techniques such as Activity-Based Protein Profiling (ABPP) shed light on previously unknown therapeutic mechanisms. In this context, ABPP technology has recently revealed a novel anti-inflammatory target of berberine, a compound extracted from traditional Chinese medicina...
